(CNN Español) – Due to the pandemic that appears to be accelerating, in the last few days, colchicine, ivermectin and plitidepsina he called the attention of the world and the experts are investigating whether to help patients with covid-19. This is what we know about these medicines.
Ivermectina
Ivermectina is an antiparasitic that has been widely used in Latin America as a preventative treatment for covid-19. However, the United States Medicines and Food Administration (FDA) does not recommend using it to prevent coronavirus.
As explained by Dr. Elmer Huerta, CNN’s public health expert and collaborator in Spanish, para filarias y las onchocercas, que causan la elefantiasis y la oncocercosis o ‘ceguera de los ríos’ of Africa ».
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“Everything took place on April 3, when a pre-publication, Australian scientist Kylie Wagstaff announced that she was using a very high ivermectin (approximately 50 times the dose she used), the drug was used in a single dose. », Explains the Dr. Huerta.
“One week after the other, Bangladeshi’s doctors communicated that habogan” cure “98% of patients who receive the combination of ivermectin and the antibiotic drug”.
Pero, como dice el Dr. Huerta, the administration of these drugs is not part of a study and “more than 90% of patients with covid-19 recover spontaneously”. It is said that it is also possible that patients recovering from the use of ivermectin.
Currently, multiple scientific studies can demonstrate the usefulness of the drug against the covid-19.
However, a recent revision of 11 meta-analysis studies on the drug, conducted by Liverpool University investigators under the auspices of UNITAID, received the OMS assessment, concluding that it had no evidence that can be effective in reducing deaths by covid-19, the studies are very disparate, have many limitations, and it is not possible to Establish a definitive conclusion », says the Dr. Huerta.
In conclusion, by the way, there are no sufficient data to show that ivermectin can help patients with covid-19, as well as the 14th of January the National Institutes of Health (INS).
Colchicina
Colchicine is an anti-inflammatory drug extract from a European plant that has been used since antiquity to alleviate pain in joints and joints.
Since then they have been used to control gothic attacks, enforced in that the person is unable to eliminate the acidic acid and the crystals accumulated in the articles.
How to explain the Dr. Huerta, it is thought that the drug tends to have a positive effect against the covid-19 in controlling the so-called “cytoquine disorder”, the inflammatory response that is the main cause of pulmonary complications and death from coronavirus.
In recent days, the Colchicina has received a press release from the 22nd of January of the Institute of the Correa Montreal, affiliated with the University of Montreal in Canada.
According to the communication, in a study with 4,159 patients diagnosed with covid-19, it was found that colchicine reduced in 25% hospitalizations, in 50% the need for mechanical ventilation and in 44% deaths, and comparison with the patients who receive a placebo.
Without embarrassment, the Dr. Huerta afirma that we should hope for more details about the usefulness of the medicine to treat the covid-19 pues “the advertisement was received by a press release, and does not mean the publication of a scientific study”.
This is an important aspect that can “during the pandemic we have many announcements about the apparent utility of medicines that are solid without a solid scientific basis, such as hydroxychloroquina, for example, and that end in failure.”
Agreed with the Dr. Huerta, «our tocons hope that the authors will publish the results of their study in a scientific review revised by par. While so, we highly recommend that you do not seek medical help. The drug, which by itself has a therapeutic margin, is very likely to cause secondary effects, such as severe, diarrheal, bloody and painful vomiting ».
Plitidepsina
Plitidepsina is an antiviral drug that, like ivermectin, has been tested in an in vitro study, “it is said in the laboratory, in single-tube tubes, with cellular cells”, explains Dr. Huerta.
The study, dubbed “Plitidepsin has a potent preclinical efficacy against SARS-CoV-2 in directing eEF1A host protein”, was published in the journal Science.
Sin embargo, al ser un stududio in vitro, según el Dr. Huerta, «it is very initial, can not be salted from the tube of the tooth to the people, to the patient. This is another example of how we can use plums to analyze the efficacy of medicines ».