The demand for vacancies against the COVID-19 supersedes the global summit, and so much the frustrated population as the governors who want to know more. Much more. Ahora mismo.
The problem, indicates the evacuation specialist Maria Elena Bottazzi, from the Baylor Faculty of Medicine, is that “we can not add more water to the soup”.
The manufacturers of cars against the COVID-19 need to sell everything well to increase the production to tens of thousands of doses, and every little one can produce a demo. Some of its ingredients have not been produced at the enormous volume needed now.
And the apartment proposals are clear because other factories change their production to make the new vacancies can be applied for a day for another. This week, the French pharmaceutical company Sanofi announced the unusual decision that it would help to invest and pack some vacancies produced by its competitor Pfizer and its German company BioNTech. But these doses are not emphatic to read the vernacular, and Sanofi has the space available in its German factory only because it has returned to its own vacancy, which is notorious for total summers to global levels.
“We think, well, it’s good, its like men’s shirts, ¿verdad? Simply put another site where hacerlas ”, said Dr. Paul Offit, of the Philadelphia Children’s Hospital, assessor of the state governing body in vacancy matters. “It’s simply not easy.”
VARIOUS VACANCIES, DIFFERENT RECEIVES
The different classes of vacancies that are used in different countries train in order to recognize the new coronavirus, mainly the glucoprotein that it recovers. But it requires distinct technology, excellent materials, equipment and supplies.
The vacancies authorized by the United States of America, Pfizer and Modern, are encoding a fragment of genetic code called mRNA – the instructions for this glucoprotein-inside of a small ball of grass.
Manufacture small amounts of mRNA in an easy-to-use research laboratory, but “before that, we had several million doses, not 100 million, not even one million million doses of mRNA”, said Dr. Drew Weissman, of the University of Pennsylvania and that would help develop the mRNA technology.
Please do not hesitate to multiply the ingredients to get more. Creating mRNA involves a chemical reaction between genes and genetic elements, and Weissman signaled that the enzymes do not function in such a large way in large quantities.
The AstraZeneca vaccine, which is used in Great Britain and other countries, and which hopes to launch Johnson & Johnson, is being produced with a free-flowing virus that lives on the glucoprotein gene in the body. Its manufacture is very different: live cells of this virus are grown in huge biorreactors, before they are extracted and purified.
“If the cells are old or old or old, they can change, they can carry me,” said Weissman. “There are many more variables and many more things that teens can figure out.”
A more classic variety, the “inactive” virus vacancies as made by China Sinovac, require more steps and a biosecurity enhanced because it is made with dead coronavirus.
However, all vacancies have in common: Deben manufactures strict standards that require installations that carry out specific inspections and tests every step of the way, which take time but are necessary to maintain confidence in the quality of all the conditions.
WHAT HAS THE SUMINISTRO’S CHAIN?
Production depends on obtaining sufficient material. Pfizer and Moderna insist that they have reliable proof.
Aun asi, a spokesman for the United States governing body who has logistics experts working directly with the car manufacturers to anticipate and solve any summit problem.
The Director-General of Modernity, Stephane Bancel, reconsiders that he himself has challenges.
The company maintains production within 24 hours of the day, in the sense that if it “lacks a material, we can not make products, and its capacity is always lost because we can not compensate”, explained only the inversionists.
Pfizer has temporarily reduced the number of entrances in Europe during various weeks in order to make the best in its Belgian factory and increase production.
And on occasions the remedies are short. AstraZeneca is a member of the European Union, which is also embedded in the principle of lower doses of the drug. The motive quoted: a minor production of the hope in some manufacturing centers in Europe.
But in other industries, when it comes to biological ingredients “there are things that can be bad and that are bad”, said Norman Baylor, director of vacancies in the Food and Drug Administration of the United States (FDA for its sails in English) and descriptive as habitas the variations of production.
CUÁNTO SE ESTÁ FABRICANDO?
It varies by country. Moderna and Pfizer hope to add 100 million doses to the United States for the March finals and another 100 million in the second quarter of this year. And presidents, Joe Biden, have drafted the planes of compiling a total duration of the verano para vacunar to 300 million de estadounidenses in total.
The CEO of Pfizer, Albert Bourla, said this week at a Bloomberg conference that his company will hold 120 million doses for the March finals, because it will accelerate its production because it will allow sanitary staff to take an extra dose of each bottle.
But take six doses to make five require the use of specialized jingles, and have doubts about the global summit. United States sends lots with special jingles with each Pfizer cargo, indicating a vocation from the Department of Health and Human Services.
Pfizer has also announced that the best in its Belgian factory will cause molestation now to receive benefits in the largest space, and that the changes will increase global production to 2,000 million doses are already in place of the 1,300 million predicted in principle.
Modern advertising also means that it will be possible to add 600 million vacancies in 2021, by only the 500 million forecast in principle, and that it will increase its capacity to spend millions of dollars.
But it is possible that the most common form of prescribing more dosage is that other vacancies will not work. It is hoped that soon there will be study dates on the efficacy of the pharmacy of a dose of Johnson & Johnson, and another company, Novavax, is in the final phase of testing.
OTRAS FAMILY
During the months, the main company firms will carry out “manufacturer’s contracts” in the United States and Europe to help produce the dosage and complete its application. Modern, for example, works with the Swiss Lonza.
Fuera de los países ricos, El Serum Institute of India, has manufactured an environmental product of the dose de la vacuna de AstraZeneca. It is the world’s largest manufacturer of vacancies, and it is hoped that it will be a key provider for developing countries.
But some local people are trying to outdo them. Brazilian research institutes in Spain are making millions of doses of the AstraZeneca and Sinovac vaccines, but they have not yet commented on the introduction of ingredients from China.
In addition, Bottazzi said, the world also has to maintain the production of vaccines against polio, sarampi, meningitis and other diseases that follow during pandemics.
Weissman, an expert at the University of Pennsylvania, is a patient of the patient.
“I believe that every month we have more vacancies than the one before”, dijo.