When it comes to releasing the AstraZeneca vaccine with an atypical affluence of sanguine coagulants, the Johnson & Johnson, based on the same technology, is blank on the various suspects. What do you mean by respect?
What was observed?
In both cases, the various suspects are able to detect various Thrombosis cases in evacuated persons.
No simple thrombosis is treated, as are phlebitis, without afecciones muy inwoners. First of all, by its location: affecting the cerebral veins and in the minor area, the abdomen, indicates the March of the European Medicines Agency (EMA) on Johnson & Johnson (J&J), have heard the same comments on April 13 on AstraZeneca.
These pathologies are present at a level with a level of sanguine plaques, because in the vein of blood clots, the patient can suffer from hemorrhages.
“The treatment of this particular type of blood coagulation differs from that which is normally administered”, advises the FDA and CDC Sanitary Authorities, which suspend the use of J&J in the United States.
For the EMA, hooi a “possible angle” between these common sanguine problems and the administration of the pharmacies of AstraZeneca and J&J.
These vacancies are the “probable cause” of these atypical episodes, estimated by some to be a week for an FDA official, Peter Marks.
J & J’s immunizer is authorized by the UE (including Janssen’s number), but has not yet been administered. The AstraZeneca is applied in the EU, although it does not have the approval in the United States.
What do you need?
These problems can be related to the “viral vector” vacancy technique. It is based on the fact that it supports another virus, which is modified to transport in the body genetic information capable of combating the covid.
Both use an adenovirus, a very current virus type. AstraZeneca is a chimpanzee adenovirus and J&J is a human.
“All indications are that there is an adenovirus vector”, explained on Twitter Mathieu Molimard, a French specialist in pharmacology, recording that this type of problem is not with the vacancies of Pfizer / BioNTech and Modern, which use ARN messaging technology .
For now, these pathologies are also known to be registered with another vaccine that has adenovirus, the Sputnik drug. It is authorized in 60 countries, but not in the EU or in the United States.
What are the mechanisms?
Various elements lead to an immunological reaction that is provoked by these vacancies, a “plausible explanation”, according to the EMA.
In a study published online on March 28, German and Austrian investigators have established a telephone with another mechanism known.
The phenomenon “appears clinically related to heparin-induced thrombocytopenia (TIH)”, indicates the team of leading scientists of Andreas Greinacher, of the University of Greifswald.
The TIH is an abnormal, severe and habitual immune response in some patients to an anticoagulant drug, heparin.
It is a “plausible explanation”, valued by the EMA on April 7, in the process of completing new studies.
What is the risk?
In the case of J&J, he also recorded cases of atypical thrombosis, between them a decade, all in the United States, between several million administered doses, according to data examined by the EMA.
For AstraZeneca, 287 cases were accounted for worldwide, of those 142 in the European Economic Area (EU, Iceland, Norway, Liechtenstein), the European regulator stated on March.
Last week, this body reported 222 cases registered as of April 4 in the European Economic Area and in the United Kingdom, between 34 million injections. With a balance of 18 deaths up to March 22nd.
But, as with all medicines, the key is to weigh the risks and the benefits.
“Covid-19 has a huge risk of hospitalization and decay. The combination of blood clots and large plaques that are very object-oriented, and the global benefits of the Janssen vaccine in the prevention of covid-19 are superior to the secondary effects risks “, the EMA concluded on March, as stated earlier in relation to AstraZeneca.
What are the risk factors?
The young women appear especially affected. The cases detected with the J&J vacancy concern “persons under 60 years of age”, and “female mayors”. In AstraZeneca, some of the cases are listed in “60 Minutes Women’s”, according to the EMA.
Pero es demasiado temprano para sacar volggtrekkings. For now, “we have not identified any specific risk factor”, the regulator commented on the pharmacies.
In addition, various countries have decided to use the AstraZeneca vaccine for a fixed term: 30 years in United Kingdom, 55 years in France, Belgium and Canada; 60 af Alemania y Holanda, y 65 af Suecia y Finlandia.
These funds are based on the balance between risks and benefits: since our mayor is, most likely to develop a serious covid, and have more benefits to vacate with AstraZeneca.
The authorities of the United Kingdom will distribute a graphic that demonstrates that the covid-19 has a risk for the salute of six mayors that the vacancy in editions comprised between 20-29 years. Pero in France 60-69 years, the risk is 600 more important.
Norway and Denmark opt to suspend altogether the use of the AstraZeneca vaccine.