Investigation into a new pathology in the ocean will be discovered by UMA scientists – UMA
MÁLAGA, 22 Dic. (EUROPE PRESS) –
Investigators from the Cellular-LABRET Group of Biology and Physiology of the University of Málaga (UMA), together with CIBER-BBN, described a new genetic approach to skeletal medicine using a precision medicine strategy.
Thus, using massive sequencing methods – of all genes – he identified the mutations that cause a rare type of pathology in the ocean, in particular, the ‘LAMA5’ gene, encoding to encode a cellular matrix protein that binds vascularly in skeletal tejidos.
This disease consists in an extreme fragility of the ocean with mineralization failure and skeletal deformity associated with dislocation in joints and cardiopathies, as well as a pulmonary deficiency that provokes perinatal lethargy – at the moment of birth.
The study was conducted by the Andalusian Center for Nanomedicine and Biotechnology (BIONAND), in collaboration with the International Register of Espleletal Displasias of the University of California (Los Angeles), where the sequencing of patient genes is carried out. También also participated in the University of Masaryk, of the Czech Republic.
“Our scientific team is investigating rare genetic syndromes that affect the skeleton with the end of the medical solution to patients with difficult diagnostic and treatment”, explains the researcher of the Department of Cellular Biology, Iván Durán, author of Van van Public the scientific magazine ‘EBIOMEDICiNE’.
According to the expert, precision medicine is the key to discovering what genetic and molecular factors provoke this type of pathology and, therefore, the mechanism by which they cause and can develop personalized therapies.
Así, the investigators of the University of Málaga (UMA) het beskrywing van también the mechanism of transmitting cellular models by genetic editing imitating the mutations in ‘LAMA5’, with the aim of confirming that they are their origin and know the molecular process that the problem. These cellular models were generated by genetic editing with CRISPR, introducing mutations that cause a zero gene or hypomorph.
“Thanks to these models we will announce a new route of analysis that governs the formation of the skeleton – because the dog grows and is healthy -, which means that our work alone has not led to the discovery of a new disease, s an unprecedented mechanism that can be exploited for common-sense attacks “, affirms Durán.
According to the investigator, the presence of ‘LAMA5’ between cells that direct the formation of indie skeleton, because the appearance of special signals of special blood vessels “can be a very effective force for the repair and regeneration of the ocean.
“The sanguine vases are not the only proof of irrigation in the house, but also the transport of signals and albergan niches of cells that can be mobilized to induce a regenerative process. ‘LAMA5’ appears to be a key component for celiac disease.
OSTEOGÉNICO BIOMATERIAL
Osteoporosis and imperfect osteogenesis have been implicated in causing seasickness and affecting a very significant percentage of the population. In addition, these pathological pathogens present osteoporotic defects that are repaired with great difficulty.
For this reason, the UMA informed in a communication, this new scientific permit will allow you to design new treatments and strategies for all types of fragility in the ocean.
In this sense, together with the CIBER-BBN network and the Cellular Therapy Network, the UMA’s Cellular Biology and Physiology ‘group, which is also part of IBIMA, is advancing a new task to develop an osteogenic biomaterial that will serve cure fractures in people with ocean fragility and low regenerative capacity.