CIUDAD DE MÉXICO.- The success of the vacancies against the COVID-19 bases in the ARN messenger (ARNm) is using the truck to use the new technology only in other vacancies, possibly for the fibrosis cystic, it is cancerous or difficult treatment.
Scientists say the ARNm has the potential to attack nurses without being able to read conventional pharmacies.
The Emergency Authorization in United States of America’s vacancies -un Modern Inc. and other companies Pfizer Inc. and BioNTech SE- and its basic manufacturing processes have been demonstrated by the Food and Drug Administration (FDA) abierta has one more amplio of this technology has now been tried, following interviews with also experts from the ARNm camp.
Millions of dollars of capital he invested in the companies dedicated to ARNm thanks to the best expectations, tens of millions only in the last months. Yes, with the FDA’s acceptance, the camp is attracting the best scientific talent, it’s the experts.
“Once it has demonstrated that ARNm’s technology works, it will pay more attention to it,” said Glenn Hunzinger, director of the Pharmaceuticals and Biologics Division of PricewaterhouseCoopers.
Regulatory authorization for the “accelerate the process” vacancies of other therapies with ARNm, which has real evidence that it is possible to ensure the fragile components of ARNm during its manufacture and distribution, affirmed Josh Kellar, team co-director of Raad.
This technology alone compares with the operating system of a computer, allowing pharmacists to alter its lens by inserting a new genetic code in the form of ARNm, a natural chemical message that instructs the body to produce specific proteins.
The sale of vacancies is the versatility and speed of comparison with the state of the art that requires a lot of space to produce and purify the proteins and create a vacancy.
TEST OF HUMAN TREATMENTS
In 2020, due to the urgent need created by the coronavirus pandemic, more than 5,200 million dollars will be invested in companies dedicated to the development of vacancies and therapies of ARNm, up to 596 million in 2019, according to Roots Analysis, a research firm that tiene su sede af India.
In the last three months alone, CureVac NV has raised $ 518 million and Arcturus Therapeutics Holding has raised another $ 150 million. Gilead Sciences Inc. has agreed to a therapeutic vaccine against the VIH valued at up to $ 785 million with the ARNm Gritstone Oncology company.
More than 150 vacancies and therapies for ARNm are in development worldwide, according to Roots Analysis. The majority will meet in the initial phase of animal testing, for more than 30 years related to human testing.
It can be very difficult to work with the ARNm, which means that the futures of the treatments are uncertain.
The ARNm’s instructions are fugues and do not specify the body of the body where it is directed, which works well for the cells to produce an offensive fragment of the coronavirus to launch an immune response. It is most difficult to send these ordinances to a specific tether, such as the pulmonary or cardiac muscle, which require different methods of entrapment or encapsulation to protect the ARNm molecule.
The mayor’s part of the financing of this year is intended for COVID-19 projects, to allow companies to also advance with other categories of nurses.
Modern, for example, is working on treatments for cardiac diseases, cancer and rare diseases. Its most advanced COVID program is a vaccine against the cytomegalovirus, the main cause of birth defects in the United States.
Translate Bio Inc. can be the first to market an ARNm treatment if it demonstrates that its inhaled fibrous fibrosis drug is successful in extracting instructions for producing a protein known as CFTR in pulses, according to its executive president, Ronud.
The company hopes to have provisional results of an intermediate stage test in the second quarter of this year. If the results of security and efficiencies are taken into account, a further amplitude and potential potentially solicitation of the United States approval will be carried out.
People with cystic fibrosis, a pulmonary encephalitis that affects life, have mutations in the CFTR gene that make the protein function poorly or not produced at all, which leads to an accumulation of fat, which causes pulmonary infections and complications de salud grafte.
“The Mayor of Armed Forces’ posterior effects of the ARNm nurse is in the process of replacing the one that fails,” said Joe Payne, executive director of Arcturus, which is working to disable ARNm vacancies for COVID-19 and the flu, as well as medicines for hepatic diseases and cystic fibrosis.
Dr. Drew Weissman, Professor of Infectious Diseases at the Perelman School of Medicine at the University of Pennsylvania, is one of the scientists who attributes a pioneering discovery in 2005 to alter the ARNm molecular structure that is equally stable. supere the lines of defense of the body.
In the last few months, Weissman said that 20 companies working in the ARNm camp have been asked to have one of their directives, and the number of laboratories soliciting collaborators with Penn in the work of the ARNm has tripled.
While campos like cellular therapy are beginning to grow, scientists who are vanguardian workers are working on ARNm companies, said Jacob Becraft, executive president of Strand Therapeutics, who is working on ARNm control technology.
“Much of this people is appearing in my heart”, dijo.
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