Raquel Almansa, coordinator of the investigation, and Jesús Bermejo, investigating officer.
El Covid-19 more than one year ago declared a pandemic. In addition to this, there are many things that are known about coronavirus. It’s because, including, it’s high, it’s a sigh concentrating on the mayor’s part of the sciences of the scientific society. Así, a recent joint study of the group of Biomedical Investigation of Respiratory Infection and Ibsal Sepsis (Salamanca Institute of Biomedical Research) and Río Hortega de Valladolid University Hospital support that uncontrolled viral replication is what causes inflammation in the viral process.
The investigation, which involves the physiopathology of the serious disease caused by this virus and has been published in Lancet microbe, confirm more viral plasma charge, “there are major levels of inflammation, endothelial and tissue market, demonstrating that the virus plays a key role in the pathogenesis of serious illness by Covid-19 “, according to explanations given by the Council of Health of Castile and Leon to Redacción Médica.
This is va as opposed to a very extended theory which defines that, in the inflammatory phase of the disease, the virus does not judge a relevant paper. The halllazgos of the investigator group apuntan to all the contrary, ya that series “the viral replication uncontrollable that causes the inflammation”.
Antiviral treatments
En baseer ‘n estos resultados, los scientíficos sugieren seguir investigandi para find effective antiviral drugs, “deberían cuales combine with anti-inflammatory drugs which is currently administered to the most serious patients ”. In the same way, investigators insist on carrying the viral load in plasma and the presence of the antigen of the virus in his song “could be useful tools to detect patients and patients that are complicated”.
Asimismo, the study apunta a que, de la misma mannera que sucede con la Infection par VIH, The most severe patients present with a viral load of SARS-CoV-2 more plasma high, “which results in a sudden surge of a respiratory virus”. The group considered that the patients who failed presented “antigen N of the virus in the blood, which means that these patients do not have the capacity to control the replication of the disease”.
Participants and those involved in the investigation
To launch these results, the group of Biomedical Investigation into Respiratory Infection and Ibsal Sepsis and the University Hospital Río Hortega, will participate in the multicentric projects (one funded by the Canadian Institutes of Health Research, the Coronabio project, and another funded by the Health Institute Carlos III, the Ciberes-UCI-Covid project), many coordinators , Jose María Eiros and Jesus F Bermejo), a project financed by the Gerencia Regional de Salud and César Aldecoa.
Inside this project, the UCIs of the hospitals of Valladolid, Salamanca, Segovia, Palencia, Burgos and Leon “There is a significant number of samples and information”, according to the quoted sources. In addition, the group collaborates with the Salamanca Primary Investigation Unit (Apisal, led by Luis García Ortiz) and investigators of the Adención Primaria éste y oeste de Valladolid (led by Carmen García Casas) to identify chronic injuries and shortcomings. Covid-19.
Asimismo, desde los Emergency Services of the University of Valladolid’s Río Hortega University Hospital are validating clinical scales of pregnancy to assess the patient in the entrance gate of the Hospital (Raúl López Izquierdo and collaborators), and from Neumology (Félix del Campo) and Medicina Internna (Luis Inglada) are collaborating on a project to predict the risk of ingress in UCI.
This multidisciplinary work is also accompanied by the collaboration of microbiologists from the Río Hortega Hospital and the Valladolid Clinic, León, Burgos and the Principality of Asturias de Alcalá de Henares, Intensive Care Workers at the Gregorio Marañón Hospital in Madrid and Barcelona’s Vall d’Hebron Hospital The Law of Valencia, the Clinic of Barcelona, the Institute of Biomedical Research of Lleida, Internalists of the Infant Leonor Hospital of Madrid, Emergency Physicians of Gregorio Marañón, of the Biochemical Services of this same hospital, as well as the Service of Analysis Clinics and Cardiovascular Surgery at Valladolid Clinic Hospital, and finally the Viral Infection and Medicine Unit of the National Center for Microbiology. The coordination of patient recruitment led by Raquel Almansa, of the BioSepsis group, with Luis Tamayo and Elena Bustament coordinating the work at UCI.
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