The 49ers had 17 players on the injured reserve and two others, center Weston Richburg and defensive lineman Ronald Blair, who spent the entire season on the list who was physically unable to perform.
In addition, seven more players from the 53-man squad have been officially ruled out of the 49ers’ season finale on Sunday against the Seattle Seahawks in Glendale, Ariz.
Among those on the above lists, it seems likely that NFL All-Decade cornerback Richard Sherman, edge rusher Dee Ford and Richburg have already played their last games with the 49ers. And with a total of 27 players planned for unlimited free agencies, there will be quite a few players who will not be back in 2021.
Here’s a look at six players who might fit the 49ers for the last time on Sunday.