A team of Spanish scientists has mathematically described how to initiate metastasis and has developed a model that can help increase treatment for hereditary cures, organ regeneration or better development.
Investigators at the Carlos III and Complutense Universities of Madrid described it mathematically as a tumor invades epithelial cells and automatically quantifies the evolution of the tumor and the islets of cells that are already in progress.
The model he developed could be used to better understand the cellular biophysical characteristics that are implicated in the development of new treatments for hereditary curation, organ regeneration or cancer evolution.
The research analyzes the collective movement of cells in the tejidos, a process that results in essential pathological development with tumor invasion and metastasis, starting a primary pathology in physiological processes such as hereditary scarring, embryonic development or tejid reconstruction.
The researchers, who published their conclusions in the PLoS Computational Biology review, used a combination of mathematical modeling, numerical simulations, and topological analysis of simulation data results and experiments to understand how to invade cancer cells.
“A simplification of the first stages of cancer metastasis consists in that the tumor cells move as a collective and move to a collective of normal cells in a healthy tissue”, he explained the authors of the work Luis López Bonilla in Carolina Trenado, del Department of Mathematics at the University of Carlos III, and Ana Carpio, Department of Mathematics Applied to the Complutense.
‘Selecting the collections of cells used using software, simulated logos the invasion that is being produced in Tejido is safe for cancer cells, ”he said.
To automatically automate the evolution of the barrier or limit between cancerous and normal cells, researchers have used topological analysis techniques of data, as well as using them first in this type of study.
“Participating in a series of successive images based on the experiments and also of the numerical simulations, he has grouped, traced and classified the topological changes in the automated manner interfaces ahead of the cancer cells”, indicates the scientists.
The techniques developed in the field of this work can be escalated to a large volume of data and these studies are carried out by a mayor, according to the investigators, who made sure that these different techniques could be relevant in the camp of the bioengineering of tejidos to study how to affect the biophysical characteristics of distinct materials the regeneration of organs and tejidos.