Moderna announced Monday that it is starting to administer its next-generation COVID-19 vaccine candidate in a Phase 1 study. The new candidate, mRNA-1283, can be stored in a refrigerator, which could potentially facilitate storage and shipping barriers.
“We are pleased to begin this Phase 1 study of our next generation COVID-19 vaccine candidate, mRNA-1283,” Moderna CEO Stephane Bancel said in a press release on Monday. “Our investments in our mRNA platform have enabled us to develop this next-generation vaccine candidate, which is a potential refrigerator-resistant vaccine that can facilitate easier distribution and administration in a wider range of settings, including potentially for developing countries. committed to helping address this ongoing public health emergency.
The currently approved Moderna two-dose vaccine can be stored in the refrigerator for up to 30 days before use, between 2 degrees Celsius and 8 degrees Celsius, but cannot be frozen again once thawed. Unlimited bottles can be stored for up to 8 hours between 8 degrees Celsius and 25 Celsius, but can also not be frozen again.
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The new clinical trial is to evaluate three dose levels of the mRNA-1283, which targets the SARS-CoV-2 ear protein, given to healthy adults in a two-dose series 28 days apart and at one dose level in ‘ is a single shot. The results will be compared with the current authorized dose level in the two-dose range.
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“mRNA-1283 is intended to be evaluated in future studies for use as a booster dose for previously vaccinated or seropositive, as well as in a primary series for seregative individuals,” the press release reads.