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Cytoquin torment: the darkest part of inflammation in covid-19
The covid-19 ha hecho that some medical-scientific terms hayan transcended the ambit of science and related to the general population. In fact, this process works like a “scrambled phone” and the concepts are alien to some people. It is not unusual in these days to talk to people without medical or scientific knowledge about the “cytoquine torment” and always have the correct form. Well, let’s try to clarify and explain in a simple way what is called a “cytoquine torment”. With this number you can intuir that there is nothing good. What are the cytoquines? Cytoquins are their little proteins released by our cells that act as messengers between the cells of the immune system (our defenses). It is possible to coordinate an immune response in accordance with the infection and regularize the inflammation. There are many quantities, while some live on the message that there is more energy in the response (its pro-inflammatory, p. Ej. IL-1, IL-6, TNF, MCP-1), others are decir “ya es suficiente, se acabó la batalla” (son antiinflammatorias, bl. ej. IL-4, IL-10, TGF). A double filo army Normally, when a microbio enters the body, the system detects it, activates our defenses and eliminates the germen. Once the amenation has been eliminated, the immune system calms down and returns to normalcy. Without embargo, in some cases, the immune system is out of control and has no form of detention. Tenemos al enemigo en casa. In this process, the cytokines that animate (activate) have our defenses acted considerably (producing a torque) and their effect can be counteracted by the cytokines that order the end of the battle (the ones that deactivate the defenses). The result is an uncontrolled and generalized inflammatory response that is positively retrieved and that can seriously kill various organs of our body, such as the pulmon, rhinoceros, hiccup or coronation, being potentially mortal. In other words, the collateral day caused by the immune response that attempts to control the infection can be more painful than the microbiome. The citoquine torments are not exclusive to covid-19The term “citoquine torment” is intended to conjure up the most general form of covid-19. In this case, some of its effects include the attack of the immune cells on the pulmonary, the coagulation of the blood and the fall of various organs of our body. It is also observed in the most severe cases an increase in blood levels of some proteins, especially ferritin, reactive C protein and IL-6. The cytoquine test is not a new concept for immunologists and physicians. Cytoquines are produced in other infections, in autoimmune diseases (the body thinks that its properties are invasive) and in people with certain “defective” genes. For example, it is thought that the large-scale death caused by the “Spanish flu” of 1918 was due, in part, to the cytokine tumors that were produced in many of the infected people. Most recent influenza infections (2009-2014) and other coronavirus (p. Ej. The 2003 SARS epidemic) also produced cytokine tumors in an important patient number. También las bacteria can cause this pathology. A classic example is Yersinia pestis, a bacterium that has produced various pandemic pests throughout history. How do you make the tower grow? The tormentor of cytokines initiates when a large number of leukocytes (macrophages, neutrophils and mastocytes) activate abundant proinflammatory cytokines. This process can be modified with the use of drugs, although it is always taken. There are drugs that generally reduce the activity of the immune system, for example, anti-inflammatory drugs, such as steroids, which act on leukocytes. Prohibition of sin, this is medidas’ son poco selectivas, and it is not a funcionan. In addition, reducing the general form of our defenses can make the microbe that infects us invaluable, want to find a taste in our body and we will be free of them. One more effective strategy is to be more selective and direct to the subcutaneous tissues, the cytokines IL-1, IL-6 and TNF, among others. In this sense, there are more treatments that modify the activity of these fundamental cytokines for the establishment and development of the cytotoxic pathway, while maintaining a great deal of mediocrity in the rest of the operational defenses. Although many of these treatments are in the experimental phase, they are known as science, as in other cases, finally there are effective drugs to counteract this important pathology. This article was originally published in The Conversation. Lea el original.Las personas firantes no son asalariadas, ni consultoras, ni poseen acciones, ni reciben financiación de ninguna kompanía u organisación que pude obtener beneficio de este articul, and han declarado carecer de vinculos relevas mála dela academic cargo citado.