The intestinal microbiologists had an idea of how diet affects the microbiome of the intestines, but not much data to provide evidence that there is a connection. In an article published in Monday Physical Medicine, a collaboration of gut microbiome researchers at various institutions, provides the first pieces of evidence linking the diet to the gut microbiome.
The authors of the study included researchers at King’s College London, the Harvard TH Chan School of Public Health, Massachusetts General Hospital (MGH), the University of Trento, Italy, and the health science firm ZOE Global. The study, called PREDICT 1, involved more than 1,000 people in the UK and 100 people in the US
Participants in the PREDICT 1 study had the intestinal microbiome sequenced by the study authors. They also provided detailed long-term dietary information and blood samples. According to the researchers, there were significant associations between microbes and nutrients and types of food. The authors suggest that food quality (unprocessed versus highly processed), food sources (plant-based versus animal), and foods (healthy versus unhealthy) were important to overall health and microbiome ecology.
The research results suggest in particular that the diversity of healthy plant foods in the diet ‘forms the composition of the intestinal microbiome’, according to the article. Another interesting finding is that there may be microbial indicators of obesity that researchers can identify in each individual. The researchers were able to identify metabolites in the blood that could serve as biomarkers indicating the risk of cardiovascular disease.
A new paper by @cibiocm @nsegata @fasnicar is now in @NatureMedicine
#Microbiome connections to host #metabolism and habit #diet of 1,098 deeply phenotypic individuals
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– CIBIO – UniTrento (@CIBIO_UniTrento) 12 January 2021
“We were amazed to see such large, clear groups of what we informally call ‘good’ and ‘bad’ microbes, emerging from our analysis,” said Nicola Segata, professor and principal investigator of the Computational Metagenomics Lab at the University. of Trento, Italy, and the leader of the microbiome analysis in the study, according to a press release.
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The results of the study suggest that based on our diets, we can influence which microbes can survive in our intestines. Tim Spector, an epidemiologist at King’s College London, scientific founder of ZOE, the company that funded and supported the study and started the PREDICT study program, says: ‘When you eat, you not only nourish your body, you feed us the trillions of microbes that live in your gut. ”
The company plans to bring this science to the public.
“Through ZOE, we can now provide the opportunity to discover which of these microbes have in their gut,” Spector said in the press release. “Using machine learning, we have the ability to share your calculations on how your body will respond to any food.”
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The next steps for the research are to start clinical trials to test whether people can enlarge their gut microbiome by changing their diet, hopefully to increase the good microbes compared to the bad ones, according to The New York Times.
“We think there are very small changes that people can make that can have a huge impact on their health that can be mediated by the microbiome,” said Sarah Berry, a nutritionist at King’s College London and co-author of the study. . to The New York Times.
The next phases of the study, PREDICT 2, completed the data collection in 2020 as a collaboration between ZOE and Massachusetts General Hospital and Stanford University. According to Fiana Tulip, head of communications at ZOE, the main objectives for this study are to further understand the response to dietary intake, including meals and time. PREDICT 3 was launched a few months ago, according to the press release. Its goal is to validate and understand the effects of ZOE’s dietary advice on weight, health and wellness markers, ”Tulip said in an email to Changing America.
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