Llegó la primavera y hay un sensation de alivio en el aire. Despite a year of physical restrictions and distancing, more than 171 million doses of vaccines against covid-19 have been administered in the United States and around 20% of the population is fully immunized. But also there are some more around the air: the variants of the SARS-CoV-2.
I’m an expert in viruses and vaccines, which means that I do not study viruses and design and try vaccination strategies against viral infections. In the case of SARS-CoV-2, this is a mayor of sentido de urgencia. Humans are in a career to be immune to this equivocal virus, which has the ability to mutate and adapt because it is a step in the right direction for our community to be hosted. Debating the variants that are emerging, the career could be complicated.
Cinco wissel ‘n las que debemos estar atentos
The ARN virus as well as the SARS-CoV-2 constantly replicate itself. Many of these mutations result in degeneration of the virus and eventually disappear through natural selection.
Sondeverbod, occasionally offering a benefit from the mutation or the genetic variant of the virus. An example is a mutation that increases the virus’ capacity to adhere more strongly to human cells, which intensifies its ability to replicate. Another example is a mutation that allows the virus to propagate more easily from person to person and, ultimately, increase its transmission capacity.
Nothing about it is transmitted by a virus that is legally attached to the human population and has been adapted to what humans are called ‘infants’. If the virus does not live, it is governed by the same evolutionary impulse that all organisms, the primordial and perpetuate.
Currently there are five pre-occupant variants circulating in the United States: the B.1.1.7 that originated in the United Kingdom, the B.1.351. of South Africa, the P.1. registered for the first time in Brazil and B.1.427 and B.1.429 which are operated in California.
Each of these variants has a number of mutations and some of its key mutations in critical regions of the viral genome. Given that the ‘spike’ protein is necessary for the virus to adhere to human cells, there are several variants of these critical mutations. In addition, the anticoagulants that neutralize the virus typically have one of these proteins ‘spike’, which in turn sequences the protein ‘spike’ an important component of the vacancies against covid-19.
India and California receive the variable ‘doblemente mutantes’ variety because they are not one of its sido clasificadas, and he has a general interest in el mundo. It has a key mutation in the ‘spike’ protein similar to the one found in the varieties of Brazil and South Africa, and other species in the varieties of California. Currently, no variant has been cataloged as causing large consequences, although there is a preoccupation with the fact that we change and surge new variants and know more about what is being propagated.
More transmissible and causing more serious illnesses
These variants are preoccupied with various reasons. First, the pre-occupant variants of the SARS-CoV-2 are usually person-to-person propaganda with at least a percentage of between 20% and 50% the mayor facility. These allow you to infect more people and propagate more quickly and extensively, which may cause them to become prevalent.
For example, the United Kingdom variant that was first detected in the United States in December 2020 is now the most prevalent in the country and represents approximately 27.2% of all cases in March. Asimismo, the P.1 variant detected for the first time in Brazilian journeys in January is currently causing strains in these countries, which has collapsed the health care system and increased it to less than 60,000 deaths in March.
Another preoccupation aspect is that these new variants can escape the product of a natural infection or our current evacuation efforts. For example, the antibodies of the people who recovered have been infected or he received a vaccine that could not be attached to a new variant of the virus, which results in a minor neutralization of that variant. It can be repaired or a minor impact of the current monoclonal treatments or the vacancies.
On the other hand, Pfizer recently announced data from a group of volunteers in South Africa that would support a high efficiency of its MARN vaccine against variant B.1.351. Another warning note is that the immune response of the cells T produced by a natural infection with SARS-Cov-2 or a vaccine mARN reconciles the variants of United Kingdom, South Africa and Brazil. It is suggested that having a reduced neutralizing activity of anticoagulants, cell responses T estimated at vaccination or a natural infection will provide a level of protection against these variants.
Vigilante and vacant
What does it mean? Well, the current vacancies mean that there are no living conditions caused by these varieties, it is likely to avoid moderate or severe illnesses, and in particular hospitalizations and deaths. Esas son buenas notices.
What do you want to do? Follow what we are doing: using mascarillas, avoiding ventilated areas and practicing physical distance to reduce transmission and avoid new impulses for these new variants. We will also be evacuating the mayor to increase the number of people in the mayor of possible places as soon as possible to reduce the number of cases and the probability that the virus will generate new variants. And, for this, it is vital that the public health officials, the governors and the non-governmental organizations organize the renaissance to be vacated and their fair administrative administration as local as globally.
This note was translated into Spanish by Patricia Vélez.
