- The candidate for Johnson and Johnson vaccination for the coronavirus can prevent COVID-19 complications and death, as evidenced by the conclusions of the Phase 3 trial.
- The remedies require a single shot and can be stored at regular refrigerator temperatures. But the J & J COVID-19 vaccine is not as effective as the mRNAs of Pfizer / BioNTech and Moderna, which can be considered a disadvantage.
- Dr. Anthony Fauci said in an interview that these comparisons do more harm than good, and he explained that this particular vaccine is so important.
Johnson & Johnson on Friday unveiled the results of its phase 3 trial with the coronavirus vaccine and revealed to the world that the drug could prevent severe COVID-19 leading to hospitalization and death. The vaccine is safe to use and had no serious side effects during the massive phase 3 test. The company also said that the drug would work against the South African mutation B.1.351, the only new coronavirus strain shown to elude some drugs already in use.
The J&J vaccine does have some advantages that make it a unique proposition over competitors. It uses a single-shot regimen, with this vaccine candidate the only one that does not require a booster shot three to four weeks after the first jab. Unlike the pfizer / BioNTech and Moderna mRNA vaccines, the Johnson & Johnson vaccine can also stare at normal refrigeration temperatures, which means that the logistics of transporting and storing the vaccine will not be as complex.
The Johnson & Johnson candidate does not offer efficiencies consistent with the Moderna and BioNTech drugs. But this should absolutely not be a problem, said dr. Anthony Fauci said in an interview where he explains why the new vaccine is so important for the management of COVID-19 in the US and other countries.
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Fauci tells CNN Friday that the J&J candidate and the others will reduce tensions on the U.S. health care system. “If we can alleviate that, it’s really important – not only with this candidate, but also with the others who already have the Emergency Use Authorization (EUA),” he said.
Dr. Fauci pointed out the obvious benefits of the remedy. ” A vaccine that’s cheap, it’s a single dose and that has no cold chain requirements – it’s pretty good, ” Fauci said as he addressed the ‘elephant’ in the room.
The drug’s efficacy – 66% worldwide and 85% effective against serious diseases – pales in comparison to the 95% efficacy achieved by the drug Pfizer and Moderna. Fauci pointed out that the J&J results would look even better without the obvious comparison.
Do you know what the problem is? “If it was there and we did not have the Moderna 94-95% … We would have said wow, an effective vaccine of 72% that is even more effective against serious diseases is very great,” said Fauci. ‘But now we always rate it at 94 to 95%. That being said, it is a vaccine that can be used especially in developing countries to keep people out of the hospital. It has a very good efficacy against serious diseases. ”
The drug was 72% in the group of volunteers in the US Phase 3 trial.
In the months leading up to the EUA receiving the Pfizer and Moderna medicines, Fauci and other health experts said they hoped the vaccine would reach 75% efficacy, saying the higher the figure, the better it would be. be. The FDA’s emergency approval threshold has been set at 50%. The effectiveness of flu vaccine varies due to the extremely mutagenic nature of the various viruses that cause flu, and the 2019 drug version is only 45% effective. However, the flu has other effective therapies that reduce the risk of death – not just a vaccine.
The Johnson & Johnson vaccine has another immediate advantage over the others. The phase 3 trial included patients infected with at least one of the worrying new strains. It is more contagious, and the South African strain is the only one that can escape coronavirus antibodies. It is unclear how effective the other vaccines are against this strain, and the J&J drug shows 57% efficacy in South Africa, where 95% of the COVID-19 cases in the trial were caused by B.1.351.
Fauci also investigated the research on Jonson & Johnson on a two-dose regimen. The company plans to see if a two-shot regime can further increase efficiency. ‘Let’s see what it shows. It could possibly increase it to 90%, “said the health expert. “Heck, if you get 72 with a single dose, you’d think you’d do pretty well with a boost.”
The US government already has a contract to purchase 100 million vaccine doses from Johnson & Johnson. The FDA’s EUA decision is due to be announced by the end of February.
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Chris Smith started writing about hobbies as a hobby, and before he knew it, he shared his views on technological things with readers around the world. If he does not write about apparatus, he can not stay in it, although he tries desperately. But that’s not necessarily a bad thing.