A compound derived from tobacco powder opens the door to a future medicine, not only against neurodegenerative diseases, but against the processes that provoke neuroinflammation in the brain.
Belinda. Z Burgos
Agencia Latina de Noticias Medicina y Salud Pública
And since it was a Puerto Rican study, the investigation demonstrated that the 4R-named compound, more so than demonstrating neuronal overprotection, could have a protective role against the neurodeflammation characteristic of nurses such as Parkinson’s, Sclerosis.
If neurodegenerative diseases are denominated in those provoked by a process that accelerates cellular death and degeneration of the nervous tissue.
“There are many publications about this neuroprotector benefit from this compound. It is in vitro cell studies or in experimental models exposing neurotoxic substances, the compound has demonstrated that protects the neurons. In my research, we evaluate whether this compound has anything to do with neuroinflammation or cerebral palsy and the memory function, ”explained the interview with Medicine and Health Public (MSP) the Dra. Wanda Vélez Torres, Director of the Department of Biochemistry of the Central University of the Caribbean (UCC).
“It is known that the 4R compound penetrates the cerebrum and is published by a mechanism that we do not know. Inflammatory response to cerebral palsy can result in a systemic infection or a lesion directly traumatic to the cerebrospinal fluid, leading to an increase in inflammatory cysts and cerebrospinal fluid cells such as microglia (cells of the nervous system) or spinal astrocytes.
For the scientific study. the team created a system of systemic inflation in ratons and the 4R compound was injected. Evaluate and mediate distinct parameters in these models, including the memory function.
“Parameters are mediated in the region of the hippocampus and cerebral cortex. We also use ratons with the alpha-7 gene silenced (important between the communication between the periphery and the central nervous system) to know if the effect of the 4R compound has a distinct response to the mediated stem by this receptor (refractory alpha-7 gene) “, Detail.
Among the halls of the studio are found that:
- The experimental models with systematic inflammatory models that collect the 4R compound reduce the inflammatory response provoked by proinflammatory cytokines, and compare with water to those that only induce the “insult” inflammation.
- Diminution of interleukina 1 (cytoquine that is produced in large quantities when there is an infection) all over the hippocampal region as in court.
- The Mayor of the effects of composting is produced in the region of the hippocampus of cerebro, which regulates memory, emotions, among other factors.
- The 4R demonstration team restores the memory loss in the experimental models with the induced systemic inflammation model.
- The 4R compound in this same model activates the phosphorylation of neuroprotective and anti-apoptotic proteins.
- The animal model with the alpha-7 receptor supports the resulting results. It is said that the mechanism by which 4R protects the neurons, decreases neuroinflammation and increases memory capacity is not exactly linked to this receptor.
“In short, we can see that this 4R compound has a therapeutic role so that in a future it can treat acute inflammation. We will continue these studies in order to see the effects of long-term disease when there is a chronic inflammation and we will see if the neuroinflammatory effect of neurodegenerative diseases is reversed, ”he points out.