Alertan that the California variant of the COVID-19 is more contagious than the others

The emerging mutations of SARS-CoV-2 will appear as part of the natural process of virus evolution. The questions about the series are more lethal or more contagious are about responding about the market, and the main doubt for these days is that they will be able to challenge the undeveloped vacancies, putting at risk the immunization of the population and returning to the end of the pandemic.

Now, demonstrating new studies shows that the coronavirus variant has been detected in California since December is the most contagious form of virus viruses.

One of the investigations hello that the variant was extensively extracted in a San Francisco nursery during the last months, in which the other study confirmed that it was present at all the state and revealed that produced the double viral particles inside a person’s body , public publication The New York Times.

This study also suggests that this variant can further enhance the defenses of the humanitarian system and the vacancies.

If none of these studies are published in a scientific journal, the experts do not know the degree of publicity for the public health that represents this variant, and comparison with others that are also being propagated in California.

“Each time it is more convenient than, at the local level, it transmits more than the others — said William Hanage, epidemiologist at the School of Public Health TH Chan of Harvard University. But there is no evidence to suggest that it is in the same league as B.1.1.7 ”.

The variant known as B.1.1.7 belongs to the United States of the United Kingdom, where it is rapidly being converted into the dominant form of virus and sovereignty of hospitals. British medical records studies suggest that the B.1.1.7 alone is the most transmissible, being more lethal than the previous variants.

Some experts say that the new variant detected in California is preoccupying, but it is unlikely that it will generate as much love as the B.1.1.7 heizo in the UK.

Charles Chiu is a virologist at the University of California, San Francisco and is top of the list with the new variant of accident, while he was preoccupied with other investigators at the discovery of B.1.1.7 in the United Kingdom. Fue en la vispera de Año Nuevo cuando se surprendió al enconr un unvariant preventione desconocida que constituía un quarte parte des las mistras que él y sus colegas habían recolectado.

In fact, investigators from the Cedars-Sinai Medical Center in Los Angeles have also detected a large increase in the number of strains in California.

The varietal fue bautizada como B.1.427 / B.1.429 y desde entonces, los investigators ya la detectaron en 45 estados, y en otros paises como Australia, Dinamarca, México y Taiwán.

Now, in a new study that will be published online soon, Chiu and his colleagues will analyze 2172 samples of viruses collected throughout the state between September and January. In September Principles, investigators will not find signals from B.1.427 / B.1.429. Pero, a vin de enero, has been converted into the predominant variant in California.

The United Kingdom and California variants are endowed with one of the highest capacities, and the probability of being circular in the same population has increased since vuelvan increased infections and deaths, advirtió Chiu. También abre la puerta a un “pesadilla de pesadilla”: que los viruses encuentren en una misma persona, intercambien sus mutations en creen una cepa aún más peligrosa del virus SARS-CoV-2.

The new evidence that the California variant may cause the person to nurse more, and that the vacancies are less effective, should encourage more intense efforts to reduce infections., dijo Chiu. These deberían include all public health meds, as well as the massacre and limitation of the public activities, as well as a rapid, campaign evacuation campaign.

The genome of B.1.427 / B.1.429 includes three mutations that affect the critical protein spike, which the virus uses to color in human cells and converts into factories for its own production. One of these three mutations, denominated in L452R, affects the so-called receptor union domain, which helps the virus and adheres to the mayor’s firm on objective cells.

The study also found that the new variant could be more effective in evading the humanitarian system. Antibodies from persons recovering from other variants would be less effective in blocking the new variant in the laboratory. The same procedure applies when investigators use their personal knowledge of those who have been evacuated.

Without embarrassment, the effect of the variant on the apparent immunity is much less than that caused by a variant of South Africa called B.1.351.

In the laboratory, the California cephalopod is also more resistant to the neutralizing antiviral agents generated in response to vaccines against COVID-19, as well as a prevalent infection with coronavirus.

In comparison with the existing variants, the reduction of the protection was “moderate … but significant”, the investigators said.

Chiu and his fellow loggers will estimate when they originate the B.1.427 / B.1.429 comparing the mutations that surgeon from which the virus separates from its common ancestor. This analysis determined that there were fines of the primavera. To be correct, this means that the variant achieves extremely high levels in California during quizzes for two months or more.

Ahora California’s conversion to a species of viral jaw can be found in two variants. “I suspect that B.1.1.7 is missing”, said Hanage.

Chiu, without embarrassment, cree that it is possible that the B.1.427 / B.1.429 reprimand the recent review and continue to dominate the state.

The state’s scientists can obtain a mayor’s capacity to identify coronavirus mutations, potentially more lethal, with a project that advances in Congress and could raise $ 1,750 million for genomic sequencing.

For now, United States alone is mapping the genetic composition of a minuscule fraction of positive samples of the virus, but some experts say that this is how they want to go. Significantly, the propaganda process in the country of problematic mutations identified for the first time in the United Kingdom and South Africa follows a questionnaire.

The Centers for the Control of the Prevention of Uniforms of the United States (CDC, by its seals in English) are in the process of guiding their efforts, aligning with the government’s advanced detection work, under the COVID law enforcement initiative. search for other levels.

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