Alejandro Aguilera Castrejón is a Mexican who has four years and a career in Israel with the goal of conducting studies in regenerative medicine, so that little one imagines that he will protagonize the works for the development of the embryo of a furry animal of the maternal uterus.
This week, supported by a group of scientists from the Weizmann Institute of Sciences, located in the Rehovot city, 12 miles from Tel Aviv, published as the main author of an article in the journal Nature on which to measure the results of a studio that tomo varios years of “trial and error” has to develop an artificial system that allows the creation of rat embryos.
In a telephone conversation with Univision Notices, Aguilera Castrejón tells us that this is the first time in history that molecular biology specialists asoman to the “black caja” that is the uterus of mammals.
Hasta now, the podium investigators fertilize mammalian ovules in the laboratory and cultivators supported by a live uterus at a reduced time lapse and without the possibility of mirage step by step on its development.
Without embarrassment, thanks to the invention of an artificial uterus that replicated the workings of a uterine uterus, Aguilera Castrejón and the rest of Weizmann’s investigators were to continue the embryo’s cremation day by day.
The gestation period of a raton it is 20 days. The team extracts the embryo from the mother to the fifty days of gestation. In this stage, a human being will have a fetus.
Delicate procedure
The artificial undeveloped uterus is a machine composed of diez frascos de vidrio que giran en un carrete in order that the embryos extracted from their mothers do not adhere to the paredes, situation that they deform and by which they die; in addition, the team has an incubator that consumes nutrients that allow the continuity of its growth.
“What we use is a general medium that is suer”, aseguró the biologist from the University of Mexico Autonomous University. “The acid is a component that is basically a matter of the song and is basically all the nutrients. For example, in the song the human beings also have their sugar and the nutrients that our food lives on ”.
“What we are extracting is the supremacy of the song of the rats and human umbilical cord, también de la sangre de humanos adultos. These nutrients are those that live on the embryo and control the percentage of oxygen and carbon dioxide that the embryos need ”.
The pressure of the gases in the artificial atmosphere and the glucose its other elements that also Aguilera says are tenien that control to log the development of the embryos.
During five days, the scientific origin of Ecatepec, in the State of Mexico, observed the cremation of the embryos up to no powder can feed more than one placenta and wall.
“The logical idea is to develop an artificial song system in which powder can be connected to an umbilical cord that allows the powdered embryos to create more,” he said.
A question expressed as to how long it would take for the science to unravel the maddening embryos of mammals in the exterior of the walls, Aguilera Castrejón assured that this possibility is and remotely. “It is said that we are a hundred years old, but we believe and do not believe that there is any reason to be concerned about in a futuro cercano the embryos can nacer of this form”.
“Our objective is not only to create embryos that can be used in an ‘in vitro’ system. Our objective is mainly to study como, at the age of five, when the embryo is extracted, the body is composed of a cell type and will form the organs and the tejidos into it once ”.
Create organs, the objective
The 28-year-old explains that at the moment developing embryos from the uterus of its mother from day one. “An embryo is a single cell, so the power to begin as one cell generates all the trillions of cells in an animal is our objective and many scientists”.
The advances, dijo Aguilera Castrejón ayudará a que se puender entender will form the organs of the embryo from a cell of an animal (including the human sera) and in a future “recapitulate the cell cultivars for creating human organs”.
The artificial uterus used in the tests can allow the investigators, now, to learn more about what the embarrassing terminations in abortions or where the fertilized eggs are not implanted.
In addition, there is a new venture regarding coma mutations or genetic deletions affecting fetal development. The investigators can, in addition, observe how the individual cells migrate to their final destinations.
