MADRID, 17 Dic. (EUROPE PRESS) –
Japanese investors have tested that the activation of only one gene to produce proteins that control the genes is sufficient to convert cells from rat ratios directly into cells that ovulate and include can fertilize like ovules, published in the magazine. If a simple method is used to promote a new drug to produce cytoplasm specialized in reproductive medicine.
In addition to proportioning new knowledge about the mechanisms of the development of the ovules, the investigation can lead to a simple route for generating highly exclusive specializations of ovocytes for its use in biology and reproductive medicine.
Almacenados in the corpse hadta that maduran and were gathered in ovulos lists for fertilization, the ovocytos represent the first step in the creation of a new human life.
The ovocytes are extremely unique in their ability to produce the most frequent types of cells needed to differentiate an individual, and a key to this capacity is the complex of cytoplasmic fluid sustainability.
The ovocytes and their cytoplasm are so extraordinary that they replace the nucleus that contains AND from an ovulation by a cell of the body, a process called nuclear transfer of somatic cells, which can produce a new life, as demonstrated by the famous Dolly.
For this, a fundamental compensation of the ovocytes and their development is important for advancing in reproductive medicine as to understand better how to propagate the life, per the knowledge of the many genes that orchestrate the development of the ovocytes that are be complete.
Analyzing the development of rat ovocytes, the investigators led by Katsuhiko Hayashi, Professor of the Faculty of Medical Sciences of the University of Kyushu, he has also identified gene for the transcendent proteins as known as important factors. of the ovocytes sino that also can directly convert the cells of the ratons into cells similar to the ovocytes.
“Initially, it was completely unbelievable to see that the cells of the mother-in-law tomaban the form of ovocytes tan fast and easily based on the introduction of only a few factors, for repeated experiments demonstrated that you were – said Nobuhiko Hamazaki, first author study that informs about the results and assistant professor at the University of Kyushu at the time of the investigation–. Discover that ocho factors of transcription podrioan conduct a cambios tan grandes fue bastante surprendente “.
Working in collaboration with RIKEN investigators, the Hayashi group discovers that as many cells as embryonic brain cells, such as induced multipotent cells (iPS), which can be created from adult cellular cells, should be kept constant the joint. of ocho transcription factors, being only four factors sufficient in some cases even with reproducibility.
“It is noteworthy that the cells can be converted directly into cells similar to the ovocytes without following the sequence of steps that are naturally formed”, Hayashi concludes.
When cultivated in the presence of other cells that are generally located around the ovocytes, the cells similar to the ovocytes develop structures similar to the ovarian cells with an abnormal chromosomal structure. At this point, the mature cells appear and the ovary can fertilize in vitro and exhibit a temperate development, and some include progressing to an even stage.
Although the nuclei modified by the cells are similar to ovocytes, they can not be used in large spaces, there is no problem for the applications that mainly require the cytoplasm of the ovary, as for reproductive and mitochondrial biology studies, which are part of the ovocytes to prevent the mothers from transmitting to their nurses related to the mitochondria.
“The cytoplasm of ovocytes is an incalculable resource in biology and reproductive medicine, and this method can produce a new herringbone to produce large quantities without any invasive procedure – according to Hayashi–. en ratones son muy prometedores “.