How are we, how are our protégés and what are the secondary effects of producer 4 of the vacancies against the COVID-19

In addition to the various technologies used to obtain vacancies against COVID-19, the four are approved by the most important independent bodies (United States and Europe) he demonstrated a high efficiency, very superior to the 50% required by the OMS as a limit for its approval.

Everything has happened so quickly that surgen tres preguntas that a new document intends to respond base in the publications and press releases of the producer companies, as well as in the information of the two regulatory agencies: the Administration of Foods and Medicines of the States (States FDA), and EEUU, and the European Medicines Agency (EMA) in Europe.

The FDA has approved for its administration in the EU the vacancies produced by the companies Pfizer / Biontech, Moderna and Johnson and Johnson / Janssen, from which it hopes to approve the EMA soon.

For its part, the EMA has authorized the Pfizer / Biontech, Moderna and AstraZeneca / Oxford vehicles. All of them have undergone clinical trials aborting dozens of miles of people and some are extensively administering to the population.

To obtain the approval of the regulatory agencies, las company vacancies manufacturers need to conduct clinical trials involving tens of thousands of people. The four companies have carried out these studies in different countries, with different ranges of editions and distinct moments of the pandemic. Import? Sí. About all because in the last months he appeared variants of the virus that can transmit with the mayor’s facility and including partially evade the immune response.

In each case, a phase III termination period has been completed, each vacancy has been assigned an efficiency rate, a well-being approach has protected the losers who have received the vacancy with respect to those receiving a placebo. The efficacy of these clinical trials vacancies will be realized later (AstraZeneca / Oxford and J & J / Janssen), in the presence of new variants of the virus, is minor. It is therefore difficult to compare the efficiency of the four vacancies.

Another important difference has to do with the rank of edades. The AstraZeneca / Oxford clinical trials include more than 65-year-olds who can not be judged on their efficacy in this segment of the population. For many countries only to administer to more young people.

The most affected adverse effects

In clinical trials, too, it is necessary to analyze relevant aspects that give an idea of ​​other benefits of the vacancies. In general, the vacancies must reduce the number of people who become infected, the number of serious cases, the degree of severity and the hospitalization and the number of deaths. A summary of the extracted data from the clinical trials is shown in the following table.

The dementia of serious cases lies in the application of the vaccine is very important. Both the UCI and its members, however, as indicated in a recent article, there are many cases in the placebo group as well as in the vacancies.

In the four vacancies, the adverse reactions reported in clinical trials are very similar and do not differ significantly from the observations for the vacancies that are applied since they were born.. Some differences are observed depending on the intensity, which can be moderate, but can always be reduced to two days with analgesic prescription of habitual prescription. No vacancies were observed in severe cases.

He was accused of observing allergic reactions which, by being extremely unfortunate, are classified as “of uncommon frequency”. These, unfortunately, he remit three rapid interventions. It is therefore recommended to rest and watch one 15-30 minutes behind the administration.

Pero the study of the adverse effects of the vacancies does not finalize a time approved. Vigilance has the final effect of detecting any effect in the evacuation process. It has published the third-party pharmacovigilance information of the AEMPS, in which it did not report any adversity not described for the vacancies approved, when it was administered millions of doses.

Once the vacancies have been approved by the Regulatory Agencies, the studies will begin with the final decision on the completion of the vacancy. It is not compared between vacancies and placebo, it is between vacancies and persons without vacancies.

Although it is ready to announce these results, there are many dates. Many of these data are processed by Israel, because they have agreed with Pfizer / Biontech to gain access to their vacancies for information on the incidence of illness during evacuation campaigns. Well, in Israel the hospitalizations and deaths between the 65-year-old mayor have been abruptly stopped. Therefore, it seems that the effectiveness of the vaccine will be very high in its efficiency, it is estimated at only 90%. And the same can hope for the other three vacancies.

In comparison mode, the flu vaccine, which is administered massively throughout the year, has an effectiveness that ranges from 40 to 60%.

I know that these vacuas work and are safe. It is hoped that this will increase the number of others that will increase the number, which will eliminate the transmission of the virus or adapt it to new variants.

What is indisputable is that now, as a society, the return of vacancies is possible in the public with these four vacancies and those that are approved. Es onuitsienlike para atajar la pandemie.

It is not easy to compare the efficiency of these vacancies but it is clear that it is much superior to the others that are routinely administered, such as the flu. And if you can compare the secondary effects. These boys are similar, and the mayor of the houses (if surgen) is in 24-48 hours, attenuated with analgesics. However, vacancies are routinely applied to babies.

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