The scientists from the Institute of Inquiry of the Center Medical Infantil of the University of Texas Southwestern (CRI) identify the specialized entity, known as a niche, in which an ocean-going medium produces new eggs and human cells.
The study, published in the journal ‘Nature’, also shows that the estimation induced by the movement is necessary for the maintenance of this niche, as well as the hose and the training cells that contain it. Together, these hallucinations identify a new form in which self-esteem represents the dogs and the immunological function.
Investigators at Professor Morrison’s Laboratory found that the fumes created in the corridor were transmitted from the oblique surfaces to the larynx of the arteriolar vascular vessels up to the middle of the jaws. The formative cells of the esophagus that recover the exterior of the arterioles detect these furs and are induced to proliferate.
It is not only the formation of new oocyte cells, which help to grow the ovaries, but the ovarian cells also secrete a secretory factor that increases the frequency of the ovarian cysts. The linocytes are the B and T cells that allow the immune system to fight infections.
By disabling the capacity of the hues forming cells to detect the pressure caused by the motion, it also converts with mechanical forces, reduces the formation of new osasous cells and foci, which is what the hues are capable of bacterial infection.
“While we are considering, the entourage of our Cassia Cube medium and the responsible cells to maintain the skeletal ocean mass and the immunological function is agotan. We are very little about how we change this entourage or why these cells are diminished with the edema –señala Sean Morrison, director of the CRI and researcher at Instituto Médico Howard Hughes–. Previous investigations have shown that ownership can improve the ocean force and the immunological function, and our study will discover a new mechanism by which it is known “.
The work in front of Morrison’s laboratory reveals the cells of skeletal mother that then lie in the majority of the new cells of the ocean that are formed during the adult edema in the ocean medium. Its leptin + receptor cells (LepR +). Form the exterior of the sanguine vases in the oceanic medium and form the factors of critical crime for the maintenance of the celery producers.
Morrison’s laboratory has also discovered that a subset of LepR + cells synthesizes a factor in the formation of hair that has not been found to be known as osteolectin. Osteolectina promotes the maintenance of the adult skeleton in order to make LepR + form new oseas cells.
In the current study, Bo Shen, postdoctoral fellow at Morrison’s Laboratory, analyzed more closely the subtext of LepR + cells that produce osteolectin. Discover that these cells reside exclusively around the arterial vascular vesicles in the oceanic medium and that mantienen progenitors linfoides cercanos synthesizing the mother cell factor (SCF), a crime factor of which depend on their cells.
The elimination of SCF from the positive cells for osteolectin agotos linfoides progenitors and socavó the ability of the ratons to mount a immune response to the bacterial infection.
“In addition to our previous work, the hallmarks of this study show that the positive cells for osteolectin create a niche specialized for lineage progenitors and oesophageal sphincter formers – results Shen–. increase the formation of the ocean and the human resources, especially in the seniors “.
Shen discovered that the number of lineage progenitor cells and positive cells for osteolectin decreases with age. With curiosity about whether you can reverse this tendency, you should be careful not to overdo it. Discovered that the hats of these ratons are fortified with the erection, while increasing the number of positive cells for osteolectin and linear progenitors around the arterioles. This is the first indication that the mechanical estimation regulates a niche in the oceanic medium.
Discovered that the positive cells for osteolectin express a receptor in its surfaces, known as Piezo1, which sends signals inside the cell in response to mechanical forces. When Piezo1 is eliminated from the positive osteolectin cells, these cells and the lineage progenitors are sustained, debilitating the hues and causing the immune responses.
“We believe that we have encountered an important mechanism by which the ownership promotes the immunity and strength of the dogs, in addition to other mechanisms predominantly identified by others,” Morrison said.