(CNN Español) – The vaccine against Russian coronavirus Sputnik V from Russia has a 91.6% efficacy to prevent covid-19 coagulation and 100% efficacy to prevent severe infections, following a provisional analysis of phase 3 data published in the medical review The Lancet el martes. The mayor is part of the adversarial events reported by the living degree.
How is the review process published? El Dr. Gustavo Cerler, director of Docencia and Investigación de Fleni and editor of the revista The Lancet, worked with Nacho Girón in the Redacción program. This is the conversation:
What does it mean that the vaccine rushes Sputnik V has a 91.6% efficiency certificate now for this issue?
The magazine Lancet published a manuscript originating from the Gamaleya Institute, which states that in its Phase 3 study with more than 20,000 patients, there is a protection index that exceeds 91%. There are about 100 patients who are evacuated, less than 10 of whom can be admitted. This is a very good number and compares favorably with the other vacancies that are available in the market in different parts of the world. The other important date is that the adverse effects do not have a lament. It has a slightly adverse effect, a pseudogripal frame, but the security profile is very good, very solid and also effective.
It is the third important point that in the group of mayors of 60 years — as you know, is the group most vulnerable and where the covid has its fatal illnesses in mayor proportion — it is also protected in the analysis subgroup. De hecho, in this phase 3 publication also published in this group the protection of fue equivalent to the rest. It looks like its three dates are a huge leap forward with a classic technology that we will be exploring a priori an array of these characteristics.
To put in context a little that happens with the Sputnik V, approve your scientific and medical knowledge to consult: What is the difference between the Sputnik V vaccine and some of the known vaccine vaccines that are exactly what we speak?
There is, in fact, the directive that there are great types of vacancies: the Russian vaccine Sputnik V, together with the AstraZeneca, Oxford, uses a vehicle to deliver what we call antigen — which is a molecule that will prevent the response del huésped— usan a vehicle that its virus, an animal virus that is not pathogenic to the male and that llega hasta the cell, is the vehicle with which the antigen has the cell.
Everything is not involved in coronavirus, meaning that it is another virus that is not pathogenic. Además, is disarmed to be able to replicate. This molecule enters the cell and the cell recognizes as extraneous. (it is one of the proteins of the capsule of the virus) and makes antibodies against that protein and in this way it generates the immune system.
The vaccine causes the use of different viruses, one of the first in which we know the first dose, and the second second to the 21 days with a different virus.
This is the technology platform of the Sputnik V vehicle, which is similar to the AstraZeneca vehicle and carries many other vehicles against other infectious agents that exist.
The Modern Vaccine or Pfizer uses another mechanism based on the ARN: introduce an ARN of the virus that generates this immunological response.
Versoen son son dos dos mechanismos distintos. The Pfizer and Moderna booth is very new. It’s a technology that has not been used until now. But in terms of real life in terms of real life, in terms of the vacancies of vacancies, tienen numbers are quite similar ones and others, the one that is probably because there are many appearances — there are many vacancies that are in the phase of experimentation temperament— and as the demand is so high, because the entire public sector is a potential candidate to vacate, there are probably many vacancies. There are many vacancies, different types, used in different parts of the world in terms of availability and offer.
So its interesting dates, different technologies, but good results.
Como is the editor The Lancet in spain and know the internal processes of this prestigious scientific publication, what is the revision process for couples who run The Lancet and what exactly is with the publication of the last hours?
The parity revision process is a system that is used many times in practice in all series of revisions, and means that even if you have a manuscript, this manuscript will be sent to experts in the year in which its references, references, are not involved , which does not have any relationship with those who wrote the manuscript (so there is no conflict of interest) and analyzes all the dates, basically looking for the results that are consistent with the conclusions. And these references refer to special powders. Pueden pedirle to the authors more dates. The data base, new experiments, digams, you have to know that the data are valid for the medical community, its ceremonies and that you can include in the medical knowledge about it.
This is applied to all and by supuesto also in the vacancies, but with a medicine that is not a vacancy, with a new surgical technique. This is the habitual system where the biomedical reviews evaluate the manuscripts and try to guarantee the quality of the object. It’s what it is with this manuscript. It’s a covert process for confidentiality. O see, ours more than that we know, but it is the habitual mechanism of the reviews.
How can you influence the publication of The Lancet — maintaining its international prestige — while more people are living with that Sputnik V in the vastness of our Latin American region?
If you are also dependent on the offer, you should know that at this time we have an offer problem with all vacancies. A thing is to have a vaccine that works well in biological terms in the laboratory and otherwise it produces millions of it vaccine with the fragrances, the glass, the jeringa, the envase, the distribution, the logistics, the holiday chain. .. The logistical problem is more serious and complex than the biological problem.
We will not return the dates of the Sputnik evacuation in real time. The medicines are acostumbrados and the dates are available in a transparent form. This is important. What? Because they are related to a patient of carnival and hueso delante mío and the link that indicates that they are vacant or that they are not vacant, tengo that saber came fue to that vacuna in large scale, with decades of patients, if to all the fue igual, si a algunos le fue mejor, a otros le fue peor. If you have to take special care because some vaccine is bad for people with diabetes or hypertension. Entries hold the available dates is a condition of science. One who has science, must do science with transparency of data and with accessible data from the experiments that have had results and that have implied individual policies and public sanitation.
In this sense, there is no point in trying to start vacating some of the world’s places – between the springs is Argentina – because there are just as many dates and antes, for example, from the publication of the review?
Uno staba incomodo, la verdad. When the data is available, unpublished, it is what we always are. All of them are trained in our medical practice by our master, which we have to see the data that we have in evidence and in general the regulatory systems — Anmat in Argentina, the FDA — we have the dates before authorizing a vaccine or a pharmacy, as if we were a little uncomfortable with the news of this information.
We also like to say that it is a very anomalous situation. The world is what some of us think that he has lived this very year and has seen to be compromised in his personal life, in his working life, in his sanitary structure. We have a huge and global typhoon species of all the planet and some of the habitual procedures are probably not on the side of all the proliferation in the sense that there is a stumbling block.
This is what I believe it is. With the diary of lunar verumos cuanto fue asi, pero creo todos tenemos que saber que algos cosus fueron impuestas. Some things that are uncommon in a vertigious manner and probably the demand of all the world about vacancies without curation, without any treatment, may have been said that some procedures have no effect. It’s the vimos in the vacancies, but also the vimos in the hydroxychloroquina, in an enormous amount of medicines that will prove that there is no result and that probably many hopes and expectations are in principle, the quality is not maintained by the dates.
Therefore, we insist that the data is an acknowledgment of the reality that the doctors can not ignore.