- Researchers at the University of Miami Miller School of Medicine have proven that a groundbreaking idea for the treatment of coronavirus actually works.
- Stem cell transfusions can save lives and accelerate COVID-19 recovery in patients with serious diseases that develop life-threatening ARDS.
- The stem cells migrate to the lungs and can correct the immune and inflammatory response, which reduces the so-called cytokine storms. “It’s like smart bomb technology in the lungs to restore normal immune response and prevent life-threatening complications,” said Dr. Camillo Ricordi said in a statement.
As awful as 2020 was, with COVID-19 largely responsible for the whole tone of last year, there is one important thing that does not get enough praise. It is the science that allows health officials and physicians to draw up protocols to prevent COVID-19 transmission and save more patients that eventually develop life-threatening complications. A large number of discoveries have enabled physicians to change the way they treat patients.
The introduction of blood thinners in COVID-19 therapy and drugs that can temper the inflammatory response has enabled more people to survive the battle with the terrible disease. New drugs such as monoclonal antibodies can prevent serious cases, and vaccines show great effectiveness in clinical trials to prevent COVID-19 complications. But SARS-CoV-2 is so contagious that the death toll is still high. The higher the property tax, the more deaths can be expected, although the actual death rate is quite low. That’s why the US has experienced so many deaths in recent months and more people will not survive COVID-19 in the coming months.
Vaccinations are the kind of miracle cure that can prevent deaths by teaching the immune system to prepare to deal with the virus from the moment it puts its feet into the body. But vaccines cannot be used on people who are already infected with the pathogen. This is where the world needs better therapies. A team of doctors has just found the groundbreaking treatment that could save even more lives than is currently possible. The researchers at the University of Miami Miller School of Medicine are proving a theory based on anecdotal evidence. Stem cell therapy can speed up the recovery of COVID-19 and prevent deaths.
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Some doctors have tried stem fusion in COVID-19 therapy in different countries, and American doctors have shown great success. But it was not studies that enabled the country to create new treatment protocols. New drugs, such as vaccines, must undergo randomized, double-blind studies that will undoubtedly prove to be effective and safe.
This is what the UM team did with mesenchymal stem cell infusions obtained through umbilical cord. The doctors studied 24 COVID-19 patients hospitalized in the UHealth Tower of UM / Jackson Memorial Hospital. The patients developed severe acute respiratory distress syndrome (ARDS), which occurs in other diseases and can be fatal. The patients received two infusions a few days apart, either with a placebo or the stem cells.
‘It was a double-blind study. “Doctors and patients did not know what was administered,” said Dr. Camillo Ricordi said in a statement. “Two infusions of 100 million stem cells were delivered within three days, for a total of 200 million cells in each subject in the treatment group.”
Ricordi, the senior author of the study Stem Cells Translational Medicine, is the director of the Diabetes Research Institute (DRI) and Cell Transplant Center at the University of Miami Miller School of Medicine.
The researchers found that the patient’s survival was 91% in the stem cell group, compared with 42% in the placebo group. All the patients younger than 85 who received the stem cells survived one month.
The patients on stem cells recovered faster than those in the control group. More than half of the patients treated with stem cells returned home within two weeks of the last treatment. More than 80% of the stem group recovered on day 30, compared with less than 37% in the placebo group.
“The umbilical cord contains progenitor cells, or mesenchymal stem cells, that can be expanded and provide therapeutic doses for more than 10,000 patients from a single umbilical cord,” Ricordi said. “It is a unique source of cells that are being investigated for their possible use in cell therapy applications, whenever you need to modulate the immune response or inflammatory response.”
The doctor said the university has been working with China on these therapies for more than ten years, researching stem cells for the treatment of type 1 diabetes. Stem cell therapies can be used in other diseases that cause an exaggerated immune response, not just COVID-19.
“Our results confirm the potent anti-inflammatory, immunomodulatory effect of UC-MSC (mesenchymal stem cells obtained by the umbilical cord). These cells have the ‘cytokine storm’, a characteristic of severe COVID-19, ‘
The stem cells have antimicrobial activity and lead to tissue regeneration, in addition to improving the immune and inflammatory response.
The therapy “requires only an intravenous (IV) infusion, such as a blood transfusion,” according to Ricordi. “It’s like a clever bomb technology in the lungs to restore the normal immune response and prevent life-threatening complications.” The stem cells have been found to deploy naturally to the lungs, which is the area most prevalent in COVID-19 patients who develop ARDS.
The university plans to study stem cell therapy in COVID-19 patients who do not have complications but are at risk of being intubated. If successful, the therapy can prevent the progression of COVID-19 to a serious condition where complications occur.
Although Ricordi and his team have proven that this stem cell therapy is safe and effective for COVID-19 patients, it is unclear if and when it can be used on a larger scale. The U.S. is still dealing with a record number of hospitalizations, and patients who get complications will need weeks to recover. Other countries are also experiencing massive COVID-19 training.
Chris Smith started writing about gadgets as a hobby, and before he knew it, he shared his views on technological things with readers around the world. If he does not write about equipment, he can not stay in it, even though he is desperately trying. But that’s not necessarily a bad thing.